7 References

Obesity Alters the Metabolism

  • Larsen LH, Astrup A, Pedersen SD. Obesity. In: Geissler C, Powers H. Human Nutrition. 13th ed. Oxford, UK: Oxford UP; 2017: 406 -425.
  • In: Marriott BP, Birt DF, Stallings VA, Yates AA. Present Knowledge of Nutrition. 11th ed. London, UK: Academic Press; 2020:
  • Kyle TK, Dhurandhar EJ, Allison DB. Regarding Obesity as a Disease: Evolving Policies and Their Implications. Endocrinol Metab Clin North Am. 2016;45(3):511-520. doi:10.1016/j.ecl.2016.04.004
  • Pollack A. AMA recognizes Obesity as a Disease. New York Times. June 18, 2013. https://www.nytimes.com/2013/06/19/business/ama-recognizes-obesity-as-a-disease.html.Accessed December 8, 2021
  • Report of the council on science and public health. American Medical Association website. https://www.ama-assn.org/sites/ama-assn.org/files/corp/media-browser/public/about-ama/councils/Council%20Reports/council-on-science-public-health/a13csaph3.pdf. Accessed December 8, 2021
  • NPR Media Documents. American Medical Association House of Delegates. Resolution 420 (A-13) Recognition of obesity as a disease. https://media.npr.org/documents/2013/jun/ama-resolution-obesity.pdf. Accessed December 8, 2021
  • Richard AJ, White U, Elks CM, Stephens JM. Adipose Tissue: Physiology to Metabolic Dysfunction. In: Feingold KR, Anawalt B, Boyce A, et al., eds. Endotext. South Dartmouth (MA): MDText.com, Inc.; April 4, 2020.
  • Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front Endocrinol (Lausanne). 2016;7:30. Published 2016 Apr 13. doi:10.3389/fendo.2016.00030
  • Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022;55(1):31-55. doi:10.1016/j.immuni.2021.12.013
  • Chait A, den Hartigh LJ. Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease. Front Cardiovasc Med. 2020;7:22. Published 2020 Feb 25. doi:10.3389/fcvm.2020.00022
  • Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375-C391. doi:10.1152/ajpcell.00379.2020
  • Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375-C391. doi:10.1152/ajpcell.00379.2020
  • Maurizi G, Della Guardia L, Maurizi A, Poloni A. Adipocytes properties and crosstalk with immune system in obesity-related inflammation. J Cell Physiol. 2018;233(1):88-97. doi:10.1002/jcp.25855
  • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219-246. doi:10.1146/annurev-physiol-021909-135846
  • Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977. doi:10.1126/science.aau6977
  • van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213-228. doi:10.1038/nrm.2017.125
  • Ngu A, Wang S, Wang H, Khanam A, Zempleni J. Milk exosomes in nutrition and drug delivery. Am J Physiol Cell Physiol. 2022;322(5):C865-C874. doi:10.1152/ajpcell.00029.2022
  • Stefan N, Häring HU, Hu FB, Schulze MB. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 2013;1(2):152-162. doi:10.1016/S2213-8587(13)70062-7


Down The Wrong Path: Weight Stigma and Discrimination 

  • Flegal KM, Troiano RP, Ballard-Barbash R. Aim for a healthy weight: what is the target?. J Nutr. 2001;131(2S-1):440S-450S. doi:10.1093/jn/131.2.440S
  • Healthy weight, nutrition, and physical activity (2022) Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/healthyweight/index.html (Accessed: January 10, 2023).
  • Current dietary guidelines (2020) Dietary Guidelines for Americans, 2020-2025 and Online Materials | Dietary Guidelines for Americans. Available at: https://www.dietaryguidelines.gov/resources/2020-2025-dietary-guidelines-online-materials (Accessed: January 10, 2023).
  • 2015-2020 Dietary Guidelines. Available at: https://health.gov/our-work/nutrition-physical-activity/dietary-guidelines/previous-dietary-guidelines/2015 (Accessed: January 10, 2023).
  • Ruhl, C. (2020) Implicit or unconscious bias, Implicit Bias is a type of Unconscious Bias | Simply Psychology. Available at: https://www.simplypsychology.org/implicit-bias.html (Accessed: January 11, 2023).
  • Projectimplicit (no date) Take a Test. Available at: https://implicit.harvard.edu/implicit/takeatest.html (Accessed: January 10, 2023).
  • Schimmack U. The Implicit Association Test: A Method in Search of a Construct. Perspect Psychol Sci. 2021;16(2):396-414. doi:10.1177/1745691619863798
  • Chou WY, Prestin A, Kunath S. Obesity in social media: a mixed methods analysis. Transl Behav Med. 2014;4(3):314-323. doi:10.1007/s13142-014-0256-1
  • Ata RN, Thompson JK. Weight bias in the media: a review of recent research. Obes Facts. 2010;3(1):41-46. doi:10.1159/000276547
  • Minadeo M, Pope L. Weight-normative messaging predominates on TikTok-A qualitative content analysis. PLoS One. 2022;17(11):e0267997. Published 2022 Nov 1. doi:10.1371/journal.pone.0267997
  • Stuber J, Meyer I, Link B. Stigma, prejudice, discrimination and health. Soc Sci Med. 2008;67(3):351-357. doi:10.1016/j.socscimed.2008.03.023
  • Fruh SM, Graves RJ, Hauff C, Williams SG, Hall HR. Weight Bias and Stigma: Impact on Health. Nurs Clin North Am. 2021;56(4):479-493. doi:10.1016/j.cnur.2021.07.001
  • Tomiyama AJ, Carr D, Granberg EM, et al. How and why weight stigma drives the obesity ‘epidemic’ and harms health. BMC Med. 2018;16(1):123. Published 2018 Aug 15. doi:10.1186/s12916-018-1116-5
  • Lawrence BJ, Kerr D, Pollard CM, et al. Weight bias among health care professionals: A systematic review and meta-analysis. Obesity (Silver Spring). 2021;29(11):1802-1812. doi:10.1002/oby.23266
  • Moore CH, Oliver TL, Randolph J, Dowdell EB. Interventions for reducing weight bias in healthcare providers: An interprofessional systematic review and meta-analysis. Clin Obes. 2022;12(6):e12545. doi:10.1111/cob.12545
  • Alberga AS, Edache IY, Forhan M, Russell-Mayhew S. Weight bias and health care utilization: a scoping review. Prim Health Care Res Dev. 2019;20:e116. Published 2019 Jul 22. doi:10.1017/S1463423619000227
  • Panza GA, Armstrong LE, Taylor BA, Puhl RM, Livingston J, Pescatello LS. Weight bias among exercise and nutrition professionals: a systematic review. Obes Rev. 2018;19(11):1492-1503. doi:10.1111/obr.12743
  • Gray CM, Hunt K, Lorimer K, Anderson AS, Benzeval M, Wyke S. Words matter: a qualitative investigation of which weight status terms are acceptable and motivate weight loss when used by health professionals. BMC Public Health. 2011;11:513. Published 2011 Jun 29. doi:10.1186/1471-2458-11-513
  • Cavaleri A, Short T, Karunaratne S, Chipchase LS. Weight Stigmatisation in physiotherapy: A systematic Review. Phys Ther Rev. 2016;21(1):1-9.



Type 2 Diabetes Is a Complex Chronic Disease

  • Riccardi G, Capaldo B, Rivellese AA. Diabetes Mellitus. In: Geissler C, Powers H. Human Nutrition. 13th ed. Oxford, UK: Oxford UP; 2017: 424 – 439.
  • Bell KJ, Colagiuri S, Brand-Miller J. Diabetes and Insulin Resistance. In: Marriott BP, Birt DF, Stallings VA, Yates AA. Present Knowledge of Nutrition. 11th ed. London, UK: Academic Press; 2020: 382 – 398
  • CDC.gov. 2022. National Diabetes Statistics Report | Diabetes | CDC. [online] Available at: <https://www.cdc.gov/diabetes/data/statistics-report/index.html> [Accessed 1 February 2022].
  • Petersen MC, Shulman GI. Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018;98(4):2133-2223. doi:10.1152/physrev.00063.2017
  • Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022;55(1):31-55. doi:10.1016/j.immuni.2021.12.013
  • Thornton PL, Kumanyika SK, Gregg EW, et al. New research directions on disparities in obesity and type 2 diabetes. Ann N Y Acad Sci. 2020;1461(1):5-24. doi:10.1111/nyas.14270
  • Gruss SM, Nhim K, Gregg E, Bell M, Luman E, Albright A. Public Health Approaches to Type 2 Diabetes Prevention: the US National Diabetes Prevention Program and Beyond [published correction appears in Curr Diab Rep. 2020 Jun 27;20(8):36]. Curr Diab Rep. 2019;19(9):78. Published 2019 Aug 5. doi:10.1007/s11892-019-1200-z
  • Bitra VR, Rapaka D, Akula A. Prediabetes and Alzheimer’s Disease. Indian J Pharm Sci. 2015;77(5):511-514. doi:10.4103/0250-474x.169026
  • Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013;4:37. Published 2013 Mar 27. doi:10.3389/fendo.2013.00037


Hypertension Is a Silent, Often Overlooked Disease

  • Sanders TAB. Hypertension. In: Marriott BP, Birt DF, Stallings VA, Yates AA. Present Knowledge of Nutrition. 11th ed. London, UK: Academic Press; 2020: 400 – 412
  • Seravalle G, Grassi G. Obesity and hypertension. Pharmacol Res. 2017;122:1-7. doi:10.1016/j.phrs.2017.05.013
  • Mouton AJ, Li X, Hall ME, Hall JE. Obesity, Hypertension, and Cardiac Dysfunction: Novel Roles of Immunometabolism in Macrophage Activation and Inflammation. Circ Res. 2020;126(6):789-806. doi:10.1161/CIRCRESAHA.119.312321
  • U.S. Department of Health and Human Services, Office of Surgeon General. (2020). The Surgeon General’s Call to Action to Control Hypertension. Retrieved from https://www.hhs.gov/sites/default/files/call-to-action-to-control-hypertension.pdf  [accessed 8/22/22]
  • Beet root juice: Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr. 2013;143(6):818-826. doi:10.3945/jn.112.170233
  • Flavonoids: Ellwood L, Torun G, Bahar Z, Fernandez R. Effects of flavonoid-rich fruits on hypertension in adults: a systematic review. JBI Database System Rev Implement Rep. 2019;17(10):2075-2105. doi:10.11124/JBISRIR-D-19-00050
  • Aerobic exercise: Börjesson M, Onerup A, Lundqvist S, Dahlöf B. Physical activity and exercise lower blood pressure in individuals with hypertension: narrative review of 27 RCTs. Br J Sports Med. 2016;50(6):356-361. doi:10.1136/bjsports-2015-095786
  • Ostchega Y, Fryar CD, Nwankwo T, Nguyen DT. Products – data briefs – number 364 – April 2020. Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/products/databriefs/db364.htm. Published April 24, 2020. Accessed August 22, 2022.
  • Saeed A, Dixon DL, Young E. Racial Disparities in Hypertension Prevalence and Management: A Crisis Control? American College of Cardiology. Published April 6, 2020. Accessed August 22, 2022. https://www.acc.org/latest-in-cardiology/articles/2020/04/06/08/53/racial-disparities-in-hypertension-prevalence-and-management
  • Musemwa N, Gadegbeku CA. Hypertension in African Americans. Curr Cardiol Rep. 2017;19(12):129. Published 2017 Oct 28. doi:10.1007/s11886-017-0933-z
  • Maraboto C, Ferdinand KC. Update on hypertension in African-Americans. Prog Cardiovasc Dis. 2020;63(1):33-39. doi:10.1016/j.pcad.2019.12.002
  • CDC. Hypertension Prevalence in the U.S. | Million Hearts®. Centers for Disease Control and Prevention. Published February 5, 2020. https://millionhearts.hhs.gov/data-reports/hypertension-prevalence.html
  • Ramirez, L. A., & Sullivan, J. C. (2018). Sex Differences in Hypertension: Where We Have Been and Where We Are Going. American journal of hypertension31(12), 1247–1254. https://doi.org/10.1093/ajh/hpy148Ritchey MD, Gillespie C, Wozniak G, et al. Potential need for expanded pharmacologic treatment and lifestyle modification services under the 2017 ACC/AHA Hypertension Guideline. J Clin Hypertens (Greenwich). 2018;20(10):1377-1391. doi:10.1111/jch.13364
  • Van Beusecum JP, Barbaro NR, McDowell Z, Aden LA, Xiao L, Pandey AK, Itani HA, Himmel LE, Harrison DG, Kirabo A. High Salt Activates CD11c+ Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension. Hypertension. 2019 Sep;74(3):555-563. doi: 10.1161/HYPERTENSIONAHA.119.12761. Epub 2019 Jul 8. PMID: 31280647; PMCID: PMC6687568.



Cardiovascular Disease Is The Largest Thread to American Lives

  • Getz GS, Reardon CA. Nutrition and cardiovascular disease. In: Geissler C, Powers H. Human Nutrition. 13th ed. Oxford, UK: Oxford UP; 2017: 397 – 405.
  • Sapp PA et al. Nutrition and Atherosclerotic cardiovascular disease. In: Marriott BP, Birt DF, Stallings VA, Yates AA. Present Knowledge of Nutrition. 11th ed. London, UK: Academic Press; 2020: 414 – 432
  • Who.int. 2022. The top 10 causes of death. [online] Available at: <https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death> [Accessed 1 February 2022].
  • Hackler E 3rd, Lew J, Gore MO, et al. Racial Differences in Cardiovascular Biomarkers in the General Population. J Am Heart Assoc. 2019;8(18):e012729. doi:10.1161/JAHA.119.012729
  • Grundy SM. Does Dietary Cholesterol Matter? Curr Atheroscler Rep. 2016 Nov;18(11):68. doi: 10.1007/s11883-016-0615-0. PMID: 27739004.
  • Carson JAS, Lichtenstein AH, Anderson CAM, et al. Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart Association. Circulation. 2020;141(3):e39-e53. doi:10.1161/CIR.0000000000000743
  • Patterson R, McNamara E, Tainio M, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. Eur J Epidemiol. 2018;33(9):811-829. doi:10.1007/s10654-018-0380-1
  • Tzoulaki I, Elliott P, Kontis V, Ezzati M. Worldwide Exposures to Cardiovascular Risk Factors and Associated Health Effects: Current Knowledge and Data Gaps. Circulation. 2016;133(23):2314-2333. doi:10.1161/CIRCULATIONAHA.115.008718
  • Tian D, Meng J. Exercise for Prevention and Relief of Cardiovascular Disease: Prognoses, Mechanisms, and Approaches. Oxid Med Cell Longev. 2019;2019:3756750. Published 2019 Apr 9. doi:10.1155/2019/3756750
  • Matthews CE, Chen KY, Freedson PS, et al. Amount of time spent in sedentary behaviors in the United States, 2003-2004. Am J Epidemiol. 2008;167(7):875-881. doi:10.1093/aje/kwm390
  • Elagizi A, Kachur S, Carbone S, Lavie CJ, Blair SN. A Review of Obesity, Physical Activity, and Cardiovascular Disease. Curr Obes Rep. 2020;9(4):571-581. doi:10.1007/s13679-020-00403-z
  • Vrablik M, Dlouha D, Todorovova V, Stefler D, Hubacek JA. Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?. Int J Mol Sci. 2021;22(8):4182. Published 2021 Apr 17. doi:10.3390/ijms22084182



Metabolic Health Can Be Improved But It Is Hard

  • MacLean PS, Wing RR, Davidson T, et al. NIH working group report: Innovative research to improve maintenance of weight loss. Obesity (Silver Spring). 2015;23(1):7-15. doi:10.1002/oby.20967
  • Nordmo M, Danielsen YS, Nordmo M. The challenge of keeping it off, a descriptive systematic review of high-quality, follow-up studies of obesity treatments. Obes Rev. 2020;21(1):e12949. doi:10.1111/obr.12949
  • Dinu M, Pagliai G, Angelino D, et al. Effects of Popular Diets on Anthropometric and Cardiometabolic Parameters: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials. Adv Nutr. 2020;11(4):815-833. doi:10.1093/advances/nmaa006
  • Greenway FL. Physiological adaptations to weight loss and factors favouring weight regain. Int J Obes (Lond). 2015;39(8):1188-1196. doi:10.1038/ijo.2015.59
  • Most J, Redman LM. Impact of calorie restriction on energy metabolism in humans. Exp Gerontol. 2020;133:110875. doi:10.1016/j.exger.2020.110875


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